As a former circuit board (and flex circuit) designer, I would expect vias in flex circuits to be about as reliable as in more traditional (rigid) laminates. Factors that would influence reliability include:
In the case of item #4, I would advocate for a “teardrop” shaped pad, to smooth the transition from the trace to the via pad.
This will tend to reduce fracturing where the trace enters the via pad on the flex circuit.
Read More: What is Flexible PCB
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